ULCERATIVE COLITIS-INDUCED PLEURAL DISEASE

TOPIC: Pulmonary Manifestations of Systemic Disease TYPE: Fellow Case Reports INTRODUCTION: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease, are associated with a large number extraintestinal manifestations. We presenting case induced pleural disease CASE PRESENTATION: 21 y/o man history on mesalamine who presented to the clinic persistent cough. Two months prior presentation he visited emergency department complaining stabbing chest pain dry CTA at that time showed no pulmonary embolism. However, it bilateral densities measuring up 13 mm in depth 22 circumference. The patient denied travel TB endemic areas. He is current smoker 2-pack year history. Infectious workup was unremarkable for histoplasmosis. His ESR CRP were within normal limits. A two month follow CT new enlargement old ones 18 55 Plan trans thoracic biopsy. Three weeks later biopsy, limited significant improvement resolution patient's complete based densities. DISCUSSION: Rarely, Bowel (IBD) involves space pericardium, causing inflammatory exudative and/or pericardial effusions. Most patients young, male, have UC during quiescent phase disease. manifestations can be classified as: pneumothorax, thickening, pleuritis, effusion (usually unilateral, an exudate neutrophils, may hemorrhagic). Our didn't effusion. Ongoing inflammation not prerequisite onset respiratory alterations, because bronchopulmonary develops after colectomy has been reported. abnormalities IBD present years affect any part lungs. These overt or subclinical do correlate duration IBD.Mesalamine also induce its immunologically mediated. Cessation drug needed sometimes, use corticosteroids poor response severe symptoms. continued Mesalamine without further problems. Differentiating between related pleuritis challenging. However biopsies rarely necessary mostly will show nonspecific acute chronic changes. CONCLUSIONS: involvement should considered when pleurisy developed UC. Also Mesalamine-induced real clinical entity pathogenesis REFERENCE #1: Lu, Shuming MD, PhDa; Wang, Lihua MDb; Zhang, Weisheng PhDc,*; Zhuqing MDd; Liu, Lina MDa; Yingde Meng, Hua MDa,* Ulcerative pleurisy, Medicine: July 2017 - Volume 96 Issue 30 p e7630doi: 10.1097/MD.0000000000007630 #2: Alessandro Tozzi, Maria Rosa Biagini, Carlotta Rastelli, Andrea Galli, Donatella Baldi, Stefano Milani, Pleuritis Patient Colitis, Diseases, 15, 1, 1 January 2009, Pages 158–159 #3: Moeser A, Pletz MW, Hagel S, Kroegel C, Stallmach A. Lung colitis--mesalazine-induced bronchiolitis obliterans organizing pneumonia manifestation disease? Z Gastroenterol. 2015 Sep;53(9):1091-8. doi: 10.1055/s-0041-103377. Epub Sep 14. PMID: 26367026. DISCLOSURES: No relevant relationships by Yazan Addasi, source=Web Response Ian Jackson, Carolina Landeen, Ali Nayfeh,